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Pregnancy guide if you are going to become a Mom

18 May

Body: In a woman’s life, pregnancy is one of the most exciting times and thus during this period the mothers need to very careful and conscious for the growth of their growing child. This time period starts being a great mother when these mothers come to know about their pregnancy. Once they conceive, along with that the growth of their unborn child tends to grow and below is some guidelines to keep themselves and their baby healthy during the time period of pregnancy.

First of all go to doctor for regular checkups and treatments

In India, the prenatal care at the regular intervals of time is very much important and thus it is quite helpful for a woman to keep her baby fit and fine in her womb. Most of the women have normal pregnancies and it is only due to the proper care and thus prevents pregnancy related complications. These complications could be life threatening and thus a mother needs opt be very careful during this time period. A physician specializing in obstetrics and midwives are healthcare professionals that particularize in caring for expecting mothers.

Go for healthy diet

A well balanced and healthy diet can help the mother as well as the baby to get the right nutrients.  The pregnancy always keeps in mind that the diet they take helps in the growth of their baby. The baby food intake all depends upon the diet of the mother. If the mother takes the wrong diet and goes for hard drinks then it could adversely affect the baby’s growth. Ladies are supposed to make sure that they eat good deal of whole grains, lean protein, veggies and fruits. Swordfish, canned tuna, undercooked meat, hot dogs and delicatessen meats should be fended off.

In addition, ladies may ask their doctor or midwife about considering a fish oil supplement. Fish oil contains omega 3 carboxylic acid, which are necessity for the baby’s mental capacity growth. Omega 3 fatty acids can also help out in reducing the risk of preeclampsia, which is the chosen cause of parental and fetal death.

Stay away from smoking and hard drinks

This may seem like a contributed, but both hard drinks and smoke can harm the growing baby. Smoking enhances the danger of bearing to a low-birth weight baby. Hard drinks increase the danger of a circumstance called FAS (fetal alcohol syndrome). It has been connected to heart defects, retarded growth and facial disfigurations.

Pregnancy specialist exercises

Many doctors and experts suggest that women gain amongst 25-30 pounds throughout pregnancy. Women who acquire more than the suggested amount of weight gain their risk of formulating preeclampsia and gestational diabetes. Proper exercise helps pregnant ladies to maintain standard weight. It also put in order the body for labor and finally the delivery. It not only does well for the mother, but it also does well for the baby. Researchers have shown that light exercise during this time period helps in strengthening the baby’s heart. Yoga or the great Indian meditation techniques have been practiced since centuries to cure many diseases and disorders. It helps the pregnant women to relieve stress and increase fertility who face problem in conceiving. Perform these techniques either at home or join some center to take better care of your unborn child.

About the Author:

Anna Cleanthous is a enthusiastic author who writes about various topics such as health, travel and tourism. She enjoys traveling and teaching.
My mail id: anna.cleanthous@gmail.com

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Useful Tips to Help You Prevent Itchy and Dry Scalp

19 Apr

It is very important to keep your hair and head clean if you want to maintain a healthy scalp. If you’re able to have a proper hygiene you can be rest assured of having a scalp that is far from being dry and itchy. Given below are some useful tips that will help you maintain a clean and healthy scalp. Majority of people have tried out these tips and have reaped benefits through them. Here are some of these tips:

1. It is important that you take a bath every day. When you don’t do so, dirt and other particles can get accumulated in your body; particularly in the regions surrounding your hair and scalp. Taking bath regularly ensures these particles are removed and are kept clean. When you don’t take bath daily, these particles will continue to remain in that area causing itchiness and dryness of scalp. Though you might have a valid reason for not taking bath on a particular day, you may not have any good reason in not taking bath regularly.

2. As far as possible, rely on organic products for cleansing your body and hair. When you use commercial products, the chemicals present in them could not only damage your skin but also your scalp. When chemicals are used on your hair, it can have an impact on hair as well as create dandruff. The natural properties of organic products will ensure your scalp will not get damaged and will remain healthy.

3. Its fine if you use shampoo and soaps on your head. But make sure you rinse them off thoroughly there are no occurrences of dandruff that can cause dryness and itchiness of your scalp.

4. Take some time out in massaging your hair and scalp. The best time to massage is while taking a bath. This procedure ensures that natural oils are released through scalp and this can help you prevent dryness and itchiness.

5.  If you’re having dandruff concerns, make sure to use a suitable anti-dandruff shampoo to help solve the problem. Though you may not see the desired results in a day or two, it will be visible within a few weeks. In addition to solving your dandruff problems, these products can also help you get rid of dryness and itchiness of your scalp.

6. You need to comb your hair frequently. In doing so, you’ll not only ensure natural shine of your hair, but also help scalp to release more oil. Combing also helps you get rid of dirt that gets trapped between hairs regularly.

7. Make it a habit to use clean scalp and hair cosmetics and tools. You should never use comb or any other material that is not cleaned properly.

8. Do not use combs and other accessories that are used by people who are dealing with problems relating to lice eggs and so on. In addition to facing this problem yourself, you might even have to deal with itchiness and dryness of skin.

Following all the above tips will go a long way in ensuring that you have a healthy scalp and hair. It will also help you in preventing itchiness and dryness of your scalp.

About the Author:

Nitin Ajwani enjoys networking with health care professionals and discussing nursing clogs and medical scrubs. He enjoys the challenges of creativity and attention to detail.

Arthritis – Knee Pain – A suitable solution

22 Mar

We have recently celebrated “world Arthritis Day” in big way.

The fact that 15 percent of the Indian population suffers from this crippling disease is alarming and arthritis deserves immediate attention.

“Arthritis” means inflammation of joint, that means there is pain , swelling, tenderness around joint. This simple looking word arthritis is of many types. This is important to know which kind of “Arthritis” I am suffering from. This will make you able to nip in the bud and control deadly disease of “Arthritis” easily.

In India  osteoarthritis ie degenerative arthritis which affects the knee is more prevalent in the country with every third person above the age of 70 years affected, , the incidence of rheumatoid arthritis is little less than in the West.

More then 20 crore Indians are suffering from Arthritis. Let us talk how to manage  osteoarthritis. Since this is a degenerative in nature so we should all understand how to prevent it. We can prevent by followings

  1. Reducing weight – keeping weight in normal limit according to age, height , sex and frame of body ( small, medium, large).
  2. Regular physiotherapy – strengthening muscles around knee like quadriceps and hamstrings
  3. Maintaining strong bones by keeping normal Bone Mineral Density  ( Normal value is T score  – 1 and above). Regular walking.
  4. Maintaining normal vitamin D 3 levels. Recent survey showed that health personnels are vitamin D 3 deficient to the tune of 65%. This is an eye opener report as we think that medical illness are not meant for us.

In spite of all preventive measures osteoarthritis affect people and person feels following features.

  1. Pain while climbing stairs more on coming down.  Person look for railing to catch hold.
  2. Seeking for some support to get up from sitting on ground.
  3. Experiences some cracking sound while bending knees.
  4. Avoid going to Indian toilet and prefers western commode.
  5. Usually feels pain on inner side of knee joints.
  6. Stiffness around knee joint.

And when you see there knees you find there is disturbed knee alignment.

Normal knee                                                                     Osteo-artheritic knee

Normal Knee, Dr Agrawal

You might have observed that if knee is aligned normally then there is about 7  degrees of valgus  between   femur and tibia that is leg goes outward from thigh by 7 degrees. In osteoarthritis this valgus alignment is reversed to Knee varus ie leg comes inside from thigh. Look following pictures which are self explanatory.

Cartilage is circular covering whole knee joint area and taking part in weight bearing

you can observe that weight bearing line is passing from centre and whole knee joint cartilage (circular surface ) is taking part in weight bearing.

Cartilage left is not taking part in weight bearing as the weight bearing axis is shifted to area where there is no cartilage.

Observe that in osteoarthritis inner joint space is reduced. There is extra pressure on medial side of joint. Cartilage is denuded underlying pain nerve endings are exposed and gives pain. Weight bearing line is shifted to medial or inner side of knee . therefore whatever cartilage is left is not taking part in weight bearing. Weight is borne by the inner small point focused area where there is cartilage is denuded so nerve endings are exposed to give you pain, the moment person puts weight on it.

To bring

  1. Healthy remaining cartilage to take part in weight bearing .
  2. So that weight is borne by the healthy cartilage and pain is avoided .
  3. And to off load medial or inner angle of knee joint from excess pressure.

We need to change present alignment of knee and bring back to normal one which is 7 degrees of valgus . High Tibial Osteotomy does this safely and simply. One of the ways to do HTO is shown here. A triangular piece of bone has been removed to realign the knee joint.

Inner angle is off loaded, excess pressure is removed

when you close the wedge normal alignment is achieved . By its virtue following things happen.

  1. Normal healthy cartilage start taking part in weight bearing so pain of the person goes away.
  2. Excess pressure from medial (Inner) cartilage goes away.
  3. Since inner angle is off loaded therefore cartilage  get pressure free environment to grow freely.

see the real x-ray pictures showing how they look in affected knee and what happens when HTO is performed.

                      

x-ray of osteo arthritic deformed                                                          After HTO- knee is aligned

knee with excess pressure at inner                                                        weight bearing is redistributed

angle                                                                                                                   to whole knee surface, so pain goes away

 

 

 

 

 

 

 

 

Similar problem can be tackled by Total Knee replacement surgery also especially when all three compartment of knee cartilage are damaged. In this we shave of ends of femur and tibia and replace by an artificial metal joint, which has certain life.

 

Advantages of HTO surgery.

  1. Since it is not performed at joint level so the knee joint movements are not restricted.
  2. Your god given natural cartilage is not excised.
  3. Cartilage is provided suitable pressure free atmosphere to grow.
  4. Cheaper.
  5. Can be performed in all operation theatres.
  6. Complications are negligible and are never dreadful.
Quality of Life after Knee Surgery

                        let us see how we Indians are different from west.

   How we       Indians                                    are different                                  from west  ?

   
                                                         

  • Don’t keep health budget.                                     Health insured
  • Go very late to doctors.                                         Approach doctor early
  • Good tolerance.                                                         Low tolerence
  • Very conservative                                                   Not conservative.
  • Afraid of big surgery.                                              Fear less
  • Miserly spend on health.                                        Don’t bother as are insured
  • Don’t’want to leave sitting habits and               Social custom are different

other social customs

What is the need in todays senerio is to provide best and customized treatment which is most suited to that particular person. Still there is  huge common cohort of osteoarthritic  people who can be offered either TKR or HTO. Responsibilities lie upon we doctors to see what procedure suits most to that particular person, rather then driven by many other things.

 HKO-TKR Overlap

Now world is changing , more and more importance is being given to the conservation of natural , god given things. HTO is one of these natural cartilage preserving technique . This should be used in abundance in suitable persons to provide relief to arthritic population our country ( rather whole Indian subcontinent )  who has different social customs then west.

About the Author:

Dr.A.K.Agrawal

Contact:

Email- drakagrawal@yahoo.com

Website-www.satyahospitals.com

Phone-+919415051052

Orthopedic and Joint replacement Surgeon

MBBS (Gold Medalist), M.S. (Orth.), MCh.(Orth.)

M.A.M.S.,M.I.G.O.F.(Germany),

AO International Fellow (Switzerland)

Fellow N.U.H. (Singapore)

Fellow Stanford Hospital ( USA )

Director-

Satya Trauma & Maternity Centre,Barra, Kanpur  &

Dr A K Agrawal is a renowned Orthopedic  and Joint replacement surgeon in Kanpur, North India. After doing his medical graduation and post graduation with gold medal from GSVM Medical College Kanpur he joined prestigious Jaslok Hospital & Research Centre, Mumbai. Later he joined Bombay Hospital, Mumbai where he worked with Dr K T Dholakia. He also worked in Central Institute of Orthopedics ,safdarjang Hospital,  and Dr R.M.L.Hospital, New Delhi.

Dr Agrawal did his fellowship from prestigious B G Unfall Klinik, Tubingen , Germany.

Dr Agrawal was awarded fellowship by National University Hospital , Singapore. Dr Agrawal has papers published in reputed journals . He has delivered many talks. He has travelled widely in India and abroad.

At present Dr Agrawal is consultant Ortho and joint replacement surgeon and director of Satya Trauma Centre,  Kanpur.

Eye Care Tips on Holi!

7 Mar

Holi is almost here. Dry Holi colours known as ‘Gulal’ and wet colours or ‘Rang’ were originally prepared naturally from the flowers and vegetables. However with time strong colours, chemical and artificial colours are being used.

The eyes are extremely at risk during Holi because of the use of harmful chemicals in synthetic colours which cause eye irritation / allergies and even temporary blindness.

The use of eco-friendly natural colours like herbal ‘gulals’ are now popular due to such reasons.

Some Helpful and Safety Tips: 

  • Ensure that your eyes remain protected at all times.
  • Use sunglasses or protective eye wear to protect your eyes from coloured water.
  • Use a hat or cap to protect your hair from strong chemical dyes.
  • Apply a thick layer of coconut oil on your body and hair so that the colour doesn’t stick and it can be washed

off easily later. While washing off the colour, use lukewarm water and keep your eyes tightly closed.

  • If you are travelling, keep the car windows tightly shut. Better still; avoid travelling on the day of playing

colours.

  • For children use non toxic colours.
  Leads to What to do?
 

Contact with eyes and skin

 

Irritation of eyes & skin, pain, swelling, photophobia [sensitivity to light]

 

Wash eyes with room temperature clean water. Remove contaminated clothing and wash exposed skin area thoroughly with soap and water.

 

If symptoms persist, see a doctor.

 

Eye injury with a high-speed balloon / stone

 

Severe injury, even rupturing the eyeball or causing a retinal detachment.

 

Do not attempt to clean the eye as the water may be contaminated and cause infection.

 

Shut the eye and rush to the nearest hospital.

 

Inhalation of the powders affects the respiratory tract

 

Irritation, cough or difficulty in breathing, bronchitis.

 

Move patient to fresh air. Administer oxygen if possible and assist ventilation as required.

 

If symptoms persist, see a doctor.

 

Encourage and motivate your friends to play a safe Holi this year!

Issued in public interest by Shroff Eye

 

About the Author:

Shroff Eye Hospital is India’s first eye hospital to be accredited by Joint Commission International (JCI), USA for excellence in patient care and health care delivery since 2006.

www.shroffeye.orgwww.lasikindia.inwww.pathologylabindia.com

Note:- To ensure that you receive our messages in your inbox, please add icare@shroffeye.org to your contact list, address book or safe sender list. If you do not wish to receive emails from Shroff Eye, please send us an e-mail.

1, 3, 5-Triazine and 2, 4, 6-trichloro-1, 3, 5-triazine as Antimicrobial Drugs

3 Jan

Summary

Antimicrobial drugs are used widely by the medical practitioners and doctors in the hospitals. The use of antimicrobial agents is comes under the chemotherapy. At present, fewer brand new antimicrobial agents are coming onto the market, considering this situation together with the increasing awareness of drug safety; we are facing a situation of severely limited options among antimicrobial agents. 1, 3, 5-Triazine and 2, 4, 6-trichloro-1, 3, 5-triazine are the two widely used antimicrobials with their derivatives.

 Introduction

Antimicrobial drugs had caused a dramatic change not only of the treatment of infectious diseases but of a fate of mankind. Antimicrobial chemotherapy made remarkable advances, result in the overly optimistic view that infectious diseases would be conquered in the near future [1].However, in reality, emerging and reemerging infectious diseases have left us facing a counter charge from infections. Infections with drug resistant organisms remain an important problem in clinical practice that is difficult to solve. If an improper antimicrobial agent happens to be chosen for the treatment of infection with drug-resistant microorganisms, the therapy may not achieve beneficial effect and more over, may lead to a worse prognosis. In addition, in a situation where multidrug-resistant organism shaves spread widely, there may be quite a limited choice of agents for antimicrobial therapy.

 

1, 3, 5-Triazine

The symmetrical triazine ring system is ordinarily abbreviated as s-triazine, although the designation 1, 3, 5-triazine is also common, particularly in the British literature [2]. In this convention the numbers refer to positions of the ring-nitrogen atoms. In the early German literature, the s-triazine system was known as kyanidine (cyanidine) or γ-triazine. The designation s-triazine is preferred by both chemical abstracts and the ring index. Ring nitrogen positions 1, 3 and 5 are equivalent, as are ring-carbon positions 2, 4 and 6. s– Triazine is an extremely volatile crystalline solid which melts, at 86°C and boils at 114°C at one atmosphere. It is easily soluble in ether and in ethanol at -5°C. The relatively high melting point and extreme volatility are in accord with a highly symmetrical molecular structure. Because of its volatility, s-triazine can be isolated from reaction mixtures by entrainment in a stream of nitrogen or dry air. The density of the highly refracting rhombohedral crystals has been determined to be approximately 1.38 g/cm3. The heat of combustion for s-triazine has been calculated to be 424.4, the heat of fusion, the heat of vaporization, 12.15 and the resonance energy, 20.0  kilo.cal./mole. s-Triazine exhibits a high degree of thermal stability; it can be purified without appreciable loss by repeated distillation over metallic sodium. Introduction of ring-nitrogen atoms has little effect on the boiling points but causes a linear increase in the melting points.

Fig. 1: 1,3,5 triazine

2, 4, 6-trichloro-1, 3, 5-triazine

The ease of displacement of chlorine atoms in 2,4,6-trichloro-1,3,5-triazine by various nucleophiles, in the presence of a hydrochloride acceptor usually sodium carbonate, bicarbonate, hydroxide or tertiary amines, makes this reagent useful for the preparation of mono-, di- and tri-substituted 1,3,5-triazines. The substitution of chlorine can be controlled by temperature to run in a stepwise manner.  Mono-substitution of chlorine occurs below or at 0°C di-substitution at 40-45°C and tri-substitution above 120°C. The substitution pattern also depends on the structure of the nucleophile, its basic strength and steric factors, the substituent already present in the s-triazine ring and the nature of solvent used. By controlling the temperature, time and optimization of variables, such as solvent and base, the substitution of chlorine in 2, 4, 6-trichloro-1, 3, 5-triazine with different substituent can be accomplished in one pot, if the correct order of addition of nucleophiles.

 

Justification

As resistance towards various available antimicrobial drugs is the major world-wide problem facing today. In this era there is a need for the synthesis of advanced compound showing effective activities against various existing microorganism. A considerable part of research carried out in the development of new drugs is devoted to the study of heterocyclic compounds. There are vast numbers of pharmacologically active nitrogen containing heterocyclic compounds, among the known, s-Triazine is of immense importance. Triazine shows various pharmacological actions such as antibacterial, antitubercular, antifungal, antimalarial, antiplasmodial, antiviral, antitumor, respiratory stimulant, CNS depressant and herbicidal etc. Different substitutions on triazine moiety on different position are found to posse’s different activity. It is promoted for sequential introduction of various piperazine and piperidine substituent into the triazine ring by many investigators [1, 3, 5]. Literature survey reveals that piperazine ring is important for biological activity [3-5]. Currently important antibiotics used for the treatment of microbial infections contain a piperazine ring in their structures. The piperidine structure is found in paroxetine, risperidone, methylphenidate, raloxifene, minoxidil and thioridazine pharmaceuticals. In this project work triazine is taken as a parent moiety for its antimicrobial activity. To fulfill the need of various substitutions on triazine, various piperazine derivatives are used to obtain advanced antimicrobial drugs.

Ravikumar et al. (2008) [6] showed the 3D-QSAR and molecular docking studies of 1, 3, 5-triazine-2, 4-diamine derivatives against r-RNA and reported it as a promising antibacterial translational inhibitor.

 

 

 

 

Fig. 2: Structure of 1, 3, 5-triazine and 2, 4-diamines

 Srinivas et al. (2006) [7] reviewed the antibacterial activity of a series of mono-, di-, tri-substituted 4-benzyloxy and 4-imidazoloaniline-[1,3,5]-triazine derivatives  and found that all the [1,3,5]-triazine derivatives exhibited significant to moderate activity (MIC 12.5-50 µg/ ml) against gram positive and gram negative bacteria.

 

 

 

Fig. 3: tri-substituted 4-imidazoloaniline-[1,3,5]-triazine.

 

Desai et al. (2005)[8] synthesized and studied in-vitro antimicrobial activities of 2-coumarin, 4-imidazole, 6-aryl thiourea substituted [1,3,5]- triazine derivatives. These compounds were found to possess promising activity against S. paratyphi and Enterobector. Thore et al. (2005)[9] synthesized 2, 4-bisanilino-6-[2’(3”-phenyl pyrazolin-5”-yl)   4’chlorophenyloxy-[1,3,5]-triazine. The synthesized compounds showed their antimicrobial activity against a. brassicicola, staphyloccous and lactobacillus.

 

Fig. 4: Synthesis of amino substituted [1, 3, 5]-triazine derivatives

 

 

Fig. 5: 2-coumarin, 4-imidazole, 6-aryl thiourea substituted [1, 3, 5]- triazine.

 

Zhou Y. et al. (2005) [10] assessed the synthesis of 3,5-diamino-piperidinyl triazine (DAPT)  as a novel translation inhibitor class that targets bacterial rRNA which exhibited broad spectrum antibacterial activity.

 

Fig. 6: 3, 5-diamino-piperidinyl triazine compound.

 

 Guo Zhiqiang et al. (2004)[11] assessed the synthesis of some new biologically active bis-(thiadiazolotriazines) in presence of 1,4-dioxane as solvent. Chikhalia et al. (2002)[12] synthesized and studied morpholine, pyridine and phenyl    thiourea substituted-[1, 3, 5]-triazine. The synthesized compounds were found to possess antibacterial activity against e. coli, s. aureus, s. paratyphi , p.vulgaris.

 

 

 

Fig. 7: 2-[4-(-4-chlorophenyl)-6-(3, 4, 5 trimethoxyphenyl) pyrimidin-2ylamino]-4-(morpholino)-6-(arylthioureido)-[1, 3, 5]-triazine.

 

Modha et al. (2001) [13] reported the antibacterial activity of 3, 4-dihydropyrimidin-4-ones and alkyl/aryl amino substituted [1, 3, 5]-triazine. It was found that aryl amino substituted [1,3,5]-triazine showed maximum antibacterial activity against s. albus, B. mega, S. typhosa and E.coli.

 

Fig. 8: 2,4-Bis alkyl/aryl amino-6-[5’-cyano-3’-N-methyl]-6-phenyl/p-chlorophenyl-3, 4-dihydropyrimidin-4-one-2’-yl-hydrazino)-[1,3,5]-triazine

 

Baldaniya e. al (2009) [14] several compounds viz. N’-{4-[(3-chloro-4-fluorophenyl) amino]-6-[(-aryl) amino] -1, 3, 5-triazin-2-yl} isonicotinohydrazides and N2-(Aryl)-N4, N6-dipyrimidin- 2-yl-1, 3, 5-triazine-2, 4, 6-triamines were prepared. All newly synthesized compounds had been tested for their antibacterial activity against gram (+)ve and gram (-)ve bacteria and also on different strains of fungi. Introduction of -OH, -OCH3, -NO2, -Cl and –Br groups to the heterocyclic frame work enhanced antibacterial and antifungal activities.

 

Fig. 9: Structures of substituted 1, 3, 5-triazine

Acknowledgements

The author is most grateful to K.P. Rathoure (Mrs.) for her technical and valuable comments.

 

References

  1. 1.      Patric GL., An Introduction to Medicinal Chemistry, Oxford University Press. (1995), 154-158.
  2. 2.      Walsh C, Wright G., Introduction: Antibiotic Resistance. Chemical Reviews. (2005), Vol. 105(2): 391-392.
  3. 3.      Stefania M; Maddalena R; Piero V; Paolo DR, Farmaco IL. (1999), 54(6):411-415.
  4. 4.      Elzbieta W; Monika K; Bogdan, Eur. J. Med. Chem. (2006), 41(4):519-525.
  5. 5.      Alireza F; Shahram G; Saeed E; Somayyeh N; Nasrin S; Mohammad AF; Leila B; Farshad HS; Abbas S, Bioorg and Med. Chem. Lett. (2006), 16(13):3499-3503.
  6. 6.      Ravikumar M, Mahmood SK, Sivakumari N., 3D-QSAR and molecular docking studies of 1, 3, 5-triazene-2, 4-diamine derivatives against r-RNA: Novel bacterial translation inhibitors. J of Mole Graph and Model. (2008), 26(8):1338-1352.
  7. 7.      Srinivas U, Hara Kishore K, Murthy U S N, Jayatirtha Rao V., Synthesis and Antibacterial Activity of 2,4,6-trisubstituted s-triazines. Bioorg Med Chem Lett. (2005), 15:1121–1123.
  8. 8.      Desai PS, Patel M, Chikhalia KH., Synthesis of Pyrimidine Thiazolidones and Azetidinones: Antibacterial and Antitubercular agents. J of Indian Chem Soc Jan (2005), 82: 83-85.
  9. 9.      Thore SN, Synthesis and Antimicrobial Study of Triazolo Pyrazolines and Isoxazolines Derivatives Asian J Chem. (2005), 17(4):2463-2466.
  10. 10.  Zhou Y, Gregar VE, Sun Z., Structure Guided Drug Discovery of Novel Aminoglycoside Mimetics as Antibacterial Transational Inhibitors Antimicrobial Agents and Chemother. Feb 2005, 4942-4949.
  11. 11.  Zhiquiang G, Koci J, Pour M, Stachel J, Waisser K., Synthesis, evaluation of benzimidazole derivative as antimicrobial agents. Eur. J. Med. Chem. (2002), 37:409-418.
  12. 12.  Patel RB, Desai PS, Desai KR, Chikhalia KH, J of Indian Chem Soc., Vol-45, 711-719.
  13. 13.  Modha J.J., Antibacterial Activity of Various Substituted s-triazines. Eur J Med Chem. (2006), 41:1240–1246.
  14. 14.  Mukesh M. Jotani, Bharat B. Baldaniya and Edward R. T. Tiekink., Ethyl 2-(2-acetoxy­benzyl­idene)-7-methyl-3-oxo-5-phenyl-2,3-dihydro-5H-1,3-thia­zolo[3,2-a] pyrimidine-6 carboxyl­ate. Pubmed central. (2010), 66:762–763.

About the Author:

Ashok Kumar*

Dept of Biotechnology, Himachal Institute of Life Sciences Rampurghat Road, Paonta

Sahib -173025, Himachal Pradesh, INDIA

*Corresponding Author’s Email: asokumr@gmail.com

 

Address for Correspondences:

Dr. Ashok Kumar C/O Mr. G.K. Rathoure, MAYASHIVRAJ SADAN, Gupta Colony, Railway Ganj Hardoi-241001 (UP) INDIA, Email- asokumr@gmail.com

Phone- 05852-223447, Mob- +919450501471, +919548080680

 

 

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